High-dose drug therapies often exhibit nonlinear pharmacokinetics, where changes in dosage do not result in proportional changes in drug concentration. This book explores the principles and implications of nonlinear pharmacokinetics in the administration of high-dose medications. It examines saturation kinetics, enzyme induction and inhibition, and the impact of high concentrations on drug distribution and elimination. Aimed at pharmacologists, clinical researchers, and healthcare professionals, the book provides insights into managing and predicting the behavior of high-dose drugs to ensure therapeutic efficacy and safety.
Ethan Patterson is a distinguished dermatologist specializing in nonlinear pharmacokinetics of high-dose drugs, focusing on understanding how high dosages of dermatological medications can lead to nonlinear pharmacokinetic behaviors. His research investigates the saturation of metabolic pathways, altered drug distribution, and unpredictable drug responses at elevated doses, impacting the safety and efficacy of treatments for severe skin conditions. Ethan has published extensively on the challenges and strategies for managing high-dose dermatological therapies, including dose optimization and monitoring protocols. He has developed comprehensive protocols that address nonlinear pharmacokinetics in high-dose drug administration. He also offers valuable insights and guidelines for clinicians to navigate the complexities of nonlinear pharmacokinetics in high-dose drug administration, promoting safe and effective treatment regimens for patients with severe dermatological needs.