Plasma protein binding significantly influences a drug’s distribution, free concentration, and therapeutic efficacy. This book examines the principles and implications of plasma protein binding, exploring how interactions with proteins like albumin and alpha-1-acid glycoprotein affect drug pharmacokinetics and pharmacodynamics. It discusses methods for measuring protein binding, factors that alter binding affinity, and the clinical significance of changes in protein-bound drug fractions. Designed for pharmacologists, pharmacists, and clinical researchers, the book provides a detailed understanding of the role of plasma proteins in drug action and efficacy.
Lily Graham is a distinguished dermatologist specializing in the role of plasma protein binding in drug efficacy, focusing on how the binding of medications to plasma proteins influences their therapeutic effects in dermatological treatments. Her research explores the dynamics of drug-protein interactions, including factors that affect binding affinity, free drug concentrations, and the impact on drug distribution and elimination. Lily has authored numerous studies on optimizing drug formulations and dosing strategies to enhance the efficacy and safety of dermatological medications by considering plasma protein binding characteristics. She has developed comprehensive protocols that incorporate plasma protein binding considerations into dermatological prescribing practices. She also provides comprehensive guidelines and insights for clinicians to understand and apply plasma protein binding principles in their prescribing practices, promoting more effective and targeted dermatological therapies through informed pharmacological approaches.