Renal impairment significantly affects the pharmacokinetics of many drugs, necessitating careful dosage adjustments and therapeutic monitoring. This book provides an in-depth exploration of pharmacokinetic modeling in the context of renal impairment, covering both physiological and mathematical approaches. It discusses the impact of reduced renal function on drug clearance, volume of distribution, and elimination half-life, and offers modeling techniques to predict drug behavior in patients with varying degrees of renal dysfunction. Designed for pharmacometricians, clinical pharmacologists, and healthcare professionals, the book serves as a practical guide for optimizing drug therapy in individuals with renal impairment.
Avery West is an expert dermatologist specializing in pharmacokinetic modeling in renal impairment, focusing on understanding how reduced kidney function affects the handling of dermatological medications. Her research investigates the development and application of pharmacokinetic models to predict drug behavior in patients with varying degrees of renal impairment, optimizing dosing regimens and minimizing toxicity risks. Avery has authored numerous studies on the use of modeling techniques to enhance the safety and efficacy of dermatological treatments in individuals with compromised renal function. She has developed comprehensive pharmacokinetic modeling protocols that inform safe dosing strategies for patients with renal impairments. Grace Cole is a leading dermatologist specializing in pharmacokinetic considerations in elderly patients, focusing on how aging affects the pharmacokinetics of dermatological medications. Her research explores the physiological changes associated with aging, such as decreased renal and hepatic function, altered body composition, and polypharmacy, influencing drug absorption, distribution, metabolism, and excretion in older adults. Grace has published extensively on optimizing dermatological therapy for elderly patients by adjusting dosages and selecting appropriate medications to enhance efficacy and minimize adverse effects. She has developed comprehensive pharmacokinetic protocols that tailor treatments to the specific needs of elderly patients.