Medicinal chemistry links molecular structure with therapeutic action, forming the basis for rational drug design. This book simplifies core concepts such as drug-receptor interactions, structure-activity relationships (SAR), and functional group modifications. It discusses major drug classes, mechanisms of action, metabolism, and resistance patterns. Case-based examples illustrate how chemical changes influence pharmacokinetics and efficacy. Ideal for students and early-career professionals, the book clarifies complex pathways and supports clear understanding of how chemistry drives pharmaceutical function.
Gavin Clarke is a chemical pharmacologist passionate about making medicinal chemistry more accessible to students and clinicians. He combines a strong theoretical base with real-world application, simplifying complex drug synthesis pathways and molecular interactions. His teaching style is praised for clarity and engagement, especially in courses for allied health professionals. Gavin has authored several introductory resources and visual learning tools for pharmacodynamics and structure-activity relationships. His mission is to demystify the core principles driving drug efficacy.