Understanding physiological mechanisms and their disruption in disease is essential for all health professionals. This book explains key concepts in pathophysiology, focusing on how normal function is altered in various clinical conditions. It covers cellular communication, organ function, systemic regulation, and the pathogenesis of diseases such as hypertension, diabetes, and shock. Each topic connects clinical signs and symptoms with underlying mechanisms to strengthen diagnostic thinking. The content is structured for clarity, using simplified explanations, clinical boxes, and review questions. It serves as a foundational resource for those transitioning from basic physiology to clinical medicine.
Tarryn Swanepoel is a faculty member and researcher with a background in systemic pathophysiology and organ failure mechanisms. Her scholarly contributions span cellular responses to disease, chronic inflammation, and endocrine dysfunction. She is known for integrating physiological theory with pathological changes to aid in clinical decision-making. She mentors undergraduate and postgraduate students, and is involved in curriculum reform initiatives that emphasize conceptual learning. Her community outreach also includes patient education on chronic illnesses.